In the world of health and fitness, there are constantly new discoveries and trends that are revolutionizing our understanding of how we nourish and care for our bodies. One of these emerging trends is Spermidin, a polyamine that plays an important role in our cells.
In this article we will take a deeper look into the world of spermidine and its potential role in weight loss We will also look at how spermidine works in the human body and what general functions it performs.
First of all: What exactly is spermidine?
Spermidin is a so-called polyamine, an organic compound that occurs in all living organisms. It was first discovered in human sperm discovered, hence the name, but is also found in other body fluids and tissues as well as in a Variety of foods availableA spermidine-rich diet would, for example, Wheat germ, soybeans, mushrooms, mature cheeses and certain types of fruit and vegetables.
The biological role of spermidine is diverse and complex. It is involved in involved in numerous cellular processes, including DNA synthesis, cell growth regulation and protein synthesis. However, one of the most important functions of spermidine is its Ability within the Autophagy, a natural cleansing process in which cells break down and recycle damaged components. This process is essential for cellular health and general well-being. Why we Autophagy The example of “zombie cells”, or senescent cells, makes it clear that we need them. You can find out more about this in the article about the Senescence.
Losing weight with spermidine – is there any truth to it?
Research into the link between spermidine and weight loss is still ongoing, but some studies suggest that spermidine plays a role in metabolism and could possibly also play a role in weight regulation.
A study found that the Fast, a Condition that promotes autophagy, can be enhanced by the polyamine spermidine. However, it is still being investigated whether a combination of fasting and spermidine supplementation could be beneficial.
Another research suggests that spermidine is closely linked to cell growth and is present in all living organisms. However, the exact link between spermidine and weight loss needs further investigation.
A precise statement on the topic of spermidine and weight loss cannot yet be made.
So: Does spermidine help you lose weight?
One of the main mechanisms by which spermidine can contribute to weight loss is Alteration of autophagy. This process can help regulate metabolism and influence fat burning, which can promote weight loss and overall weight loss in general.
In addition, studies have shown that dietary spermidine Show improvement in insulin resistanceImproved insulin sensitivity may help regulate blood sugar levels, which in turn may reduce hunger and thereby spermidine may support weight loss.
Did you know? Berberine is another molecule that can have a positive effect on insulin resistance. Its function is similar to that of the drug metformin. In addition, it activates the longevity path AMPK and was able to life-prolonging effect demonstrate.
Spermidine, appetite and fat burning
While the exact mechanisms by which spermidine affects appetite are not yet fully understood, there is evidence that it plays a role in Regulation of food intake Animal studies have shown that spermidine can influence eating behavior by modulating certain signaling pathways in the brain.
In addition there is Evidence that spermidine can influence fat burning. One study showed that spermidine can increase the formation of brown adipose tissue, a type of fat tissue that burns energy and contributes to thermogenesis.
Final words and conclusion on the topic of spermidine & losing weight
Regarding weight loss, there are studies that suggest that spermidine can promoting autophagy can help regulate metabolismIn addition, some studies have found that spermidine Insulin sensitivity affected, which could help regulate blood sugar levels and thus reduce hunger and have a positive effect on weight loss.
It remains to be seen what further research and studies will reveal in order to really say whether spermidine really helps with weight loss. Although an animal study has shown that the Spermidine-stimulated autophagy can lead to the reduction of body fat, but there are still no studies examining weight loss with spermidine in humans.
Sources
Books
- Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12). Link
- Pegg, A. E., & McCann, P. P. (1982). Polyamine metabolism and function. American Journal of Physiology, 243(5). Link
- Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., … Madeo, F. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11(11). Link
- Zhang, H., Alsaleh, G., Feltham, J., Sun, Y., Napolitano, G., Riffelmacher, T., … Simon, AK (2019). Polyamines Control eIF5A Hyposination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Molecular Cell, 76(1). Link
- Minois, N., Carmona-Gutierrez, D., & Madeo, F. (2011). Polyamines in aging and disease. Aging (Albany NY), 3(8). Link
- Pietrocola, F., Lachkar, S., Enot, DP, Niso-Santano, M., Bravo-San Pedro, JM, Sica, V., … Kroemer, G. (2015). Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell death and differentiation. Link
- Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374). Link
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