Spermidin, naturally occurring polyamine, which is found in our bodies and in various foods, has gained importance in recent years due to new study results. The research suggests that a higher spermidine intake or a spermidine-rich diet with reduced mortality In addition, the animal experiments give hope that spermidine is a potent agent for heart health.
In this article we will delve deeper into the topic Spermidin , discuss its benefits and possible side effects, and clarify what happens if an overdose occurs.
Brief introduction to spermidine
Spermidine is a polyamine, a type of molecule found in all living organisms. It was originally discovered in human sperm, hence the name, but it is also abundant in other body cells as well as in various food available, including Wheat germ, soybeans, mature cheeses and certain types of fruits and vegetables. You can find out more about this in our article on spermidine in food.
At the cellular level, spermidine plays a crucial role in Maintaining cellular functionOne of its most important functions is to support a process called Autophagy. Autophagy is a natural cleaning process in which cells break down and recycle damaged components to optimize cell function and ensure cell survival. As we age, autophagy changes. This impairment is one of the Hallmarks of Aging, a group of cellular processes that explain aging at the molecular level.
Spermidine side effects
To date, no serious spermidine side effects have been reported.
However, taking spermidine may cause side effects such as:
- Headache
- Palpitations
- Vomit
- Diarrhoea
- Allergies
- hypertensive crises
However, it is important to note that these side effects are rare and usually only occur when spermidine is ingested in extremely high amounts.
The recommended The maximum amount of spermidine is six milligrams per day. As long as this amount is not exceeded, no side effects are to be expected.
To minimize possible spermidine side effects, you should always stick to the recommended dosage and preferably take spermidine through a balanced and healthy diet.
Spermidine overdose – possible symptoms and consequences
A spermidine overdose can occur, if more than the recommended maximum amount of 6 mg per day is taken.
The exact symptoms and consequences of an overdose are not well documented, as spermidine is generally considered safe and no serious side effects have been reported to date.
If a spermidine overdose is suspected, it is best to seek medical attention immediately. It is also important to stop taking spermidine until further medical advice can be obtained.
Our conclusion on spermidine side effects
Spermidine, a naturally occurring molecule, is a promising molecule in the Longevity research and has not shown any serious side effects so far. However, it should be noted that a spermidine overdose can lead to undesirable symptoms.
Although these symptoms are rare and usually only occur with extremely high doses, it is always advisable to Do not exceed the recommended daily dose of 6 mg.
In summary, spermidine can be a part of a healthy diet, but as with all supplements, it should be used with caution and within recommended dosages.
Sources
Literature:
- Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., . . . Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12), 1428-1438. Link
- Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., … Madeo, F. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11(11). Link
- Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374). Link
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