In this article, we would like to present you an exciting scientific study on the molecule NMN and its effects on the eye. There are new findings from Chinese researchers who, in a Study Neuroprotective effects and mechanisms of action of NMN in a photoreceptor degenerative model of retinal detachmenthave examined. Photoreceptors generally serve to perceive light stimuli, are located in the retina of the human and animal eye and are therefore essential for vision. These photoreceptors can degenerate in certain diseases such as retinal detachment. As a result, the cells die and lead to blindness. Degeneration is also largely caused by age.
NMN as a new therapeutic agent?
To date, no drug therapy has been proven effective in treating photoreceptor degeneration in patients. Based on this fact, the researchers have developed the molecule nicotinamide mononucleotide (NMN), a NAD +-precursor and its possible effect as a neuroprotective substance. Neuroprotection is the attempt to protect nerve fibers and cells from dying using molecular biological methods, among other things.
In the present study, NMN was investigated in vivo in the eyes of mice and in vitro in 661W cells (mouse photoreceptor cells). According to the authors, the results are very promising. Numerous molecular parameters improved and thus also the inflammation. In addition, the death of photoreceptor cells was inhibited. This provides general protection for the retina. It is also noteworthy that the test subjects did not originally have an NAD+ deficiency. NAD+ is the molecule whose amount is increased by NMN as a precursor. The authors see the study as a first and important step towards a therapeutic approach to treating the degeneration of photoreceptor cells and its devastating consequences for humans.
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Chen X, Amorim JA, Moustafa GA, Lee J, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020; 12:24504-24521.
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