Treatment with nicotinamide mononucleotide (NMN) has been shown in numerous studies to be a viable strategy to address the age-related decline in NAD levels. The intake of NMN can boost NAD metabolism. This serves to maintain aspects of health in late life, thus contributing to the maintenance of Health span According to current research, it is assumed that externally supplied NMN in mammals is directly incorporated into NAD via the recycling pathway (salvage pathway). A newStudy byLynn Jee Kim(UNSW Sydney) and colleagues could now change this idea. They marked NMN with radioactive substances (isotopes) so that the path of the molecules within the organism could be traced. Mice served as test subjects.
structure of the study
These isotope labeling studiesshowed that NMN intake greatly increased the production of NAD metabolites. So far, this only confirms known research results. What was new, however, was that themarkedNMN the production ofunmarkedNAD metabolites, which in turn means that the NMN is not incorporated directly as previously assumed - at least not primarily. The mice received the NMN orally, i.e. via the mouth.
In another experiment, a cohort of mice was previously treated withAntibioticstreated to kill the bacteria in the gut (microbiome) as much as possible. Subsequent treatment with NAD precursors such as NMN resulted in an even higher number of the body's own NAD metabolites.
Results
The results are certainly remarkable, as they contradict the previously assumed model of direct incorporation of NAD precursors. Instead, the results may indicate that treatment with NMN, for example, could indirectly boost the body's own NAD metabolism. However, the mechanism for the research results is not yet clear. Based on the astonishing results of the antibiotic trial, the authors suspect that the intestinal microbiome plays a role.
Sources
Books
PREPRINT: Lynn-Jee Kim, Timothy Chalmers, Greg Smith et al. Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome. 2020. PREPRINT (Version 1) available at Research Square
https://doi.org/10.21203/rs.3.rs-87047/v1
APreprint, also known as a pre-publication, is a scientific publication that has already been made available to the (professional) public, but has not yet been peer-reviewed.
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