What is Alpha Lipoic Acid?
Alpha-lipoic acid (ALA) has been examined particularly in recent years by nutritionists and dermatologists. It is a naturally occurring compound, which is found in various foods and is known for its strong antioxidant properties What is particularly interesting is that even when applied topically (e.g. as a gel) an antioxidant effect is achieved.
It is important not to confuse alpha-lipoic acid (ALA) with alpha-linolenic acid (also abbreviated as ALA), which are two different compounds with different properties and functions. Alpha-lipoic acid is involved in energy metabolism and has been studied for its potential role in treating various health conditions. Alpha-linolenic acid, on the other hand, is an essential omega-3 fatty acid that is also found in many dietary supplements.
Where does alpha-lipoic acid occur?
Alpha-lipoic acid is found in certain foods, such as:
- Spinach (3,14 μg per g dry matter)
- Broccoli (0,94 μg per g dry matter)
- Tomatoes (0,6 μg per g dry matter)
It can also be produced in small amounts by the body itself.
Did you know?
broccoli is full secondary plant substancesthat can contribute to your health. It is not without reason that the American millionaire and longevity guru Bryan johnson broccoli every day and also takes broccoli concentrate. One of the most important molecules in broccoli is sulforaphane.
What benefits does alpha lipoic acid offer the human body?
Diabetes
Researchers have conducted a review of clinical trials examining the use of alpha-lipoic acid in people with type 1 or type 2 diabetes and symptoms of peripheral diabetic neuropathy (diabetes-related nerve damage). The study concludes that the molecule may be a treatment option for Patients with peripheral diabetic neuropathy can be considered. In addition, the study found that both parenteral and oral supplementation of alpha-lipoic acid for up to two years is safe and does not affect glycemic control.
memory loss
A study examined the effect of treatment with alpha-lipoic acid (ALA) on the cognitive performance of patients with Alzheimer's disease with and without diabetes mellitus. It is known that diabetes mellitus (DM) is a risk factor for Alzheimer's disease. Nevertheless, most diabetics have a insulin resistance (IR), which is associated with an increased risk of Alzheimer's disease. The study involved 126 Alzheimer's patients who were divided into two groups: one with diabetes mellitus and higher insulin resistance and one without diabetes mellitus. The patients' cognitive functions were assessed using various scales and questionnaires. Insulin resistance was assessed using the HOMA index.
After the study period, the researchers found that 43% of patients in DM group (26 subjects) and 23% of patients in group B (15 subjects) had significant improvement in MMSE scores (Mini Mental State Examination) compared to baselineHowever, several other values could only be improved in the DM group.
weight loss
There are two meaningful meta-analyses on the topic of weight loss. Both publications analyzed 12 studies. The first analysis found that people who took an alpha-lipoic acid supplement over a period of about 14 weeks lost an average of 0,69 kg more than the placebo groupThe second analysis examined studies with a longer treatment duration and found that the Experimental group lost about 23 kg in weight after 1,27 weeks compared to the placebo group.
Skin aging with topical application
A study in mice found that alpha-lipoic acid is deposited in the inner layers of the skin and provides antioxidant protection against the sun's harmful UV rays.
The aim of this study was to evaluate the potential of using a gel containing lipoic acid for the treatment of photodamaged skin. The results showed a significant reduction of facial wrinkles, the Removal of fine wrinkles and Improvement of skin color and texture. All this without any noticeable unwanted side effects.
Did you know?
Skin aging is a complex interplay of several factors. On the one hand, as we age, whether due to metabolic changes or UV rays, we lose more and more collagenThis molecule forms the basic structure for our skin. Likewise, our skin has less and less Hyaluronic acid, which is extremely important for hydration and reducing wrinkles.
Alpha Lipoic Acid & Longevity
In terms of longevity, alpha-lipoic acid could antioxidant properties help protect cells from damage caused by oxidative stress, which is associated with the aging process. It is found in the mitochondria, intracellular fluid, and phospholipid membranes of cells, where it may help maintain cellular health and function.
Sources
Books
- https://pubmed.ncbi.nlm.nih.gov/34553434/
- https://pubmed.ncbi.nlm.nih.gov/23293044/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723188/
- https://www.ncbi.nlm.nih.gov/pubmed/17272797
- https://pubmed.ncbi.nlm.nih.gov/26316990/
- https://www.ncbi.nlm.nih.gov/pubmed/28629898
- https://www.ncbi.nlm.nih.gov/pubmed/28295905
- https://pubmed.ncbi.nlm.nih.gov/8759036/
- https://www.ncbi.nlm.nih.gov/pubmed/24056055
- https://www.mdpi.com/2076-3921/9/10/1011
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