What is pyrroloquinoline quinone?
Pyrroloquinoline quinone, or PQQ for short, was discovered in bacteria in 1979 and in 2003 as important cofactor in metabolic processes in mammals Cofactors or coenzymes are essential for biochemical processes in the human body and support enzymes in their catalytic effect.
PQQ is thought to play an important role in the degradation of the amino acid lysine as part of redox processes. Hydrogen transfer takes place during these chemical processes. The Japanese RIKEN Brain Science Institute has already recognized PQQ as a vitamin, because it is an organic compound that is required in small quantities and cannot be produced by the body itselfPQQ must therefore be ingested with food.
It is used as a cofactor of dopamine hydroxylase, which catalyzes dopamine into noradrenaline. Research has shown that Mice fed a low-PQQ diet grew more slowly, had a weakened immune system and poor skinThey also showed reduced reproductive behavior. According to Japanese research leader Tadafumi Kato, the substance has similar functions in humans. PQQ generally counteracts cell damage and supports its treatment.
Where does pyrroloquinoline quinone occur?
PQQ, which is also known as Methoxatin is found, is due to its water-soluble property assigned to the vitamin B complex. It is found in various vegetables and meat. It is formed by different types of bacteria, but animals and humans cannot produce this substance themselves. How Ubiquinol and CoQ10 It is a highly active coenzyme that affects energy metabolismWe find PQQ in small amounts in our food. Especially in fermented products such as green Tea, kiwi, papaya, parsley, spinach, “natto” (Japanese dish made from fermented soybeans, contains nattokinase) or in breast milk.
What functions does PQQ have in the human body?
As an essential nutrient, it supports the enzyme dopamine-β-hydroxylase (DBH) in the synthesis of noradrenaline. It is one of the most important hormones in the central nervous system and the sympathetic nervous systemMedical scientific studies have shown that PQQ is involved in the vital breakdown of lysine and the associated Maintaining muscle functionLysine is an amino acid that is needed for muscle building, among other things. PQQ is involved in important metabolic processes and has the ability mitochondria to repair or rebuild.
Mitochondria are cell organelles that are responsible for the production of energy. Energy is made available to us from food by the mitochondria producing adenosine triphosphate (ATP). We find a lot of these cell organelles in muscle cells, as muscle work requires a high level of energy. As a highly effective antioxidant, PQQ described in scientific studies in connection with the healing of skin damage. Also regarding the female and male Fertility Positive effects of PQQ have been observed in medical studies.
Benefits of supplementing with PQQ
Pyrroloquinoline quinone is quite new on the market and is gaining popularity in the fitness industry due to its energy-boosting and strong antioxidant effect. Targeted supplementation supports cellular health.
- Highly effective antioxidant
- Strengthening the mitochondria, thus more energy during training
- anti-inflammatory
- Improvement of brain function through certain nerve growth factors
- Improvement of fat metabolism
- Improve sleep
- Slowing down the aging process
- Promoting cardiovascular health
- Possible positive effects on male and female fertility
Pyrroloquinoline Quinone & Longevity
In a study with the nematode Caenorhabditis elegans, it was found that PQQ could extend the lifespan of the worm, possibly through its interaction with Autophagy and insulin/IGF1 signaling.
Sources
Literature:
- https://pubmed.ncbi.nlm.nih.gov/37214340/
- https://pubmed.ncbi.nlm.nih.gov/36658601/
- https://pubmed.ncbi.nlm.nih.gov/37215170/
- https://pubmed.ncbi.nlm.nih.gov/37077928/
- https://pubmed.ncbi.nlm.nih.gov/2555337/
- https://www.nature.com/articles/nature03324
- https://pubmed.ncbi.nlm.nih.gov/35340329/
- https://pubmed.ncbi.nlm.nih.gov/34647561/
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